EGFR and pEGFR Expression in Invasive Breast Cancer
Author Information
Author(s): Magkou Christina, Nakopoulou Lydia, Zoubouli Christina, Karali Kanelina, Theohari Irene, Bakarakos Panagiotis, Giannopoulou Ioanna
Primary Institution: National and Kapodistrian University of Athens
Hypothesis
The study aims to investigate the expressions of EGFR and pEGFR and their correlation with overall and disease-free survival, clinicopathological parameters, and biological markers of invasion and angiogenesis.
Conclusion
The study provides evidence that pEGFR expression is related to angiogenesis and invasiveness, and that the EGFR/pEGFR phenotype is associated with poor patient survival in invasive breast cancer.
Supporting Evidence
- EGFR expression was positively correlated with nuclear grade.
- pEGFR was positively related to the Akt pathway and appeared to participate in invasion and metastasis.
- The EGFR/pEGFR phenotype was associated with poor overall survival.
Takeaway
This study found that certain proteins related to breast cancer can help predict how well patients will do, with some proteins linked to worse outcomes.
Methodology
A three-step immunohistochemical method was applied to paraffin-embedded sections from 154 patients with invasive breast carcinoma to detect expressions of various proteins.
Potential Biases
Potential biases may arise from the selection of patients and the retrospective nature of the study.
Limitations
The study only included women with invasive breast carcinomas and did not account for potential confounding factors in survival analysis.
Participant Demographics
Patients aged 25 to 86 years, mean age 57.12 years, all women with invasive breast carcinoma.
Statistical Information
P-Value
0.001, 0.005, 0.008, 0.049, 0.025, 0.016, 0.019, 0.013
Confidence Interval
1.573 to 27.281, 1.093 to 2.113
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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