Induction of matrix metalloprotease-1 gene expression by retinoic acid in the human pancreatic tumour cell line Dan-G
1999
Retinoic Acid and Pancreatic Tumor Cells
publication
Author Information
Author(s): Marschall Z von, Riecken E-O, Rosewicz S
Primary Institution: Medizinische Klinik I, Gastroenterologie/Infektiologie, Klinikum Benjamin Franklin
Hypothesis
Does retinoic acid affect matrix metalloprotease-1 gene expression in pancreatic tumor cells?
Conclusion
Retinoic acid increases MMP-1 gene expression in pancreatic carcinoma cells through both transcriptional and post-transcriptional mechanisms.
Supporting Evidence
- Retinoic acid results in a time- and dose-dependent increase of MMP-1 protein concentration.
- The increase of MMP-1 mRNA was partially due to an increase of MMP-1 gene transcription.
- Retinoic acid treatment results in an increase of MMP-1 mRNA stability.
Takeaway
Retinoic acid helps pancreatic cancer cells make more of a protein called MMP-1, which is important for how these cells behave.
Methodology
The study involved analyzing the effects of retinoic acid on MMP-1 gene expression in pancreatic tumor cells.
Digital Object Identifier (DOI)
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