Comparing Pancreatoduodenectomy with and without Pyloric Preservation
Author Information
Author(s): Sean P. Dineen, Christina L. Roland, Roderich E. Schwarz
Primary Institution: University of Texas (UT) Southwestern Medical Center
Hypothesis
Does pyloric preservation during pancreatoduodenectomy lead to better clinical outcomes compared to standard pancreatoduodenectomy?
Conclusion
Pyloric preservation during pancreatoduodenectomy does not lead to worse outcomes and may have some intraoperative advantages.
Supporting Evidence
- Postoperative morbidity rates were similar between the two groups.
- The median length of stay was 10 days overall, with no significant differences between groups.
- Delayed gastric emptying rates were low in both groups, with no significant differences.
Takeaway
This study looked at two types of surgery for pancreatic cancer and found that keeping the pylorus during surgery doesn't make things worse and might even make the surgery easier.
Methodology
The study reviewed clinical, operative, and pathologic data from 133 patients who underwent pancreatoduodenectomy over a ten-year period.
Potential Biases
Potential bias due to the nonrandomized nature of the study and the single-surgeon practice.
Limitations
The study is nonrandomized and may have confounding factors affecting outcomes.
Participant Demographics
The cohort included 78 women (59%) and 55 men (41%) with a median age of 66 years.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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