INK4c Expression in Multiple Myeloma Tumors
Author Information
Author(s): Dib Amel, Peterson Timothy R, Raducha-Grace Laura, Zingone Adriana, Zhan Fenghuang, Hanamura Ichiro, Barlogie Bart, Shaughnessy John Jr, Kuehl W Michael
Primary Institution: Genetics Branch, Center for Cancer Research, National Cancer Institute
Hypothesis
What is the role of p18INK4c in the proliferation of multiple myeloma tumors?
Conclusion
Most multiple myeloma tumors show increased expression of p18, despite some having bi-allelic deletion of the gene.
Supporting Evidence
- 60% of multiple myeloma tumors with a high proliferation index express increased levels of p18 RNA.
- Bi-allelic deletion of p18 occurs in about 2% of multiple myeloma tumors.
- Most myeloma cell lines express increased levels of p18 compared to normal plasma cells.
Takeaway
Some cancer cells have a gene that usually helps stop them from growing, but in many cases, they still grow too much.
Methodology
The study analyzed 40 human myeloma cell lines and 261 multiple myeloma tumors for p18INK4c expression and bi-allelic deletion.
Limitations
The study does not clarify how most tumors become insensitive to the anti-proliferative effects of p18.
Participant Demographics
The study included human myeloma cell lines and multiple myeloma tumors.
Statistical Information
P-Value
p<0.00001
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website