First-line ART Treatment Failure in Ethiopian Children
Author Information
Author(s): Birhanu Molla Yigzaw, Bekele Getamesay Molla, Endalew Bekalu, Alemu Simegn, Lashargie Cheru Tesema, Birhanu Dereje Ayalew, Mulualem Assefa, Jemberie Selamawit Shita
Primary Institution: Debre Markos University, Ethiopia
Hypothesis
What is the onset and predictors of first-line ART failure among Ethiopian children?
Conclusion
The onset of first-line ART failure among Ethiopian children is high, indicating challenges in achieving the UNAIDS target of ending the AIDS epidemic by 2030.
Supporting Evidence
- Children starting ART at an advanced WHO clinical stage had a 3.05 times higher chance of ART failure.
- Poor ART adherence increased the risk of treatment failure by 2.79 times.
- TB-HIV coinfection at ART initiation raised the likelihood of ART failure by 1.43 times.
Takeaway
This study found that many children in Ethiopia are not responding well to their first-line HIV treatment, which can lead to serious health problems. It's important to start treatment early and help kids stick to their medicine.
Methodology
A systematic review and meta-analysis of ten studies using retrospective cohort data.
Potential Biases
Potential publication bias due to asymmetrical funnel plots.
Limitations
The study may have publication bias and high heterogeneity among included studies.
Participant Demographics
Children living with HIV in Ethiopia, with varying WHO clinical stages and ART adherence levels.
Statistical Information
P-Value
0.000
Confidence Interval
95% CI: 1.91, 4.44
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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