Comparative Brain Stem Lesions in ADEM, NMO, and MS
Author Information
Author(s): Lu Zhengqi, Zhang Bingjun, Qiu Wei, Kang Zhuang, Shen Liping, Long Youming, Huang Junqi, Hu Xueqiang
Primary Institution: The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Hypothesis
To investigate comparative brain stem lesions on magnetic resonance imaging (MRI) among adult patients with ADEM, NMO, and MS.
Conclusion
Brain stem lesions showed various morphological features among adult patients with ADEM, NMO, and MS, which may help in distinguishing these diseases.
Supporting Evidence
- Patients with ADEM had a higher frequency of midbrain lesions than did patients with NMO and MS.
- Patients with NMO had a lower frequency of pons lesions than did patients with MS and ADEM.
- Lesions in patients with ADEM were usually bilateral and symmetrical, while lesions in patients with NMO and MS were asymmetrical or unilateral.
Takeaway
This study looked at brain scans of people with different diseases to see how their brain stem lesions looked. It found that the shapes and locations of these lesions can help doctors tell the diseases apart.
Methodology
Sixty-five adult patients with ADEM, NMO, and MS who had brain stem lesions on MRI were enrolled, and morphological features of brain stem lesions were assessed.
Potential Biases
As a retrospective study, bias is inevitable.
Limitations
The follow-up duration was relatively short, the study excluded children and patients without brain stem lesions, and bias is inevitable due to the retrospective nature.
Participant Demographics
The study included 65 adult patients: 17 with ADEM, 23 with NMO, and 25 with MS.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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