Ability of sera from mice treated with Ge-132, an organic germanium compound, to inhibit experimental murine ascites tumours
1985
Effects of Ge-132 on Tumors in Mice
Sample size: 20
publication
Evidence: high
Author Information
Author(s): F. Suzuki, R.R. Brutkiewicz, R.B. Pollard
Primary Institution: Kumamoto University Medical School; University of Texas Medical Branch
Hypothesis
Does Ge-132 induce antitumor activity in mice through the production of interferon?
Conclusion
Sera from mice treated with Ge-132 showed significant antitumor activity against certain tumors.
Supporting Evidence
- Sera from Ge-132 treated mice showed a 40% survival rate in tumor-bearing mice.
- Ge-132 administration resulted in a significant increase in mean survival days compared to controls.
- Interferon levels peaked 24 hours after Ge-132 administration, correlating with antitumor activity.
Takeaway
Mice given a special compound called Ge-132 were better at fighting off tumors because it helped their bodies make a substance called interferon.
Methodology
Mice were treated with Ge-132, and their sera were tested for antitumor activity against Ehrlich and RL31 tumors.
Participant Demographics
Eight-week-old male and female inbred BALB/c and C57BI/6 mice
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
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