Hair Cortisol/DHEA-S Ratios in Healthcare Workers and Their Patients During the COVID-19 Pandemic: A Case Study
2024

Hair Cortisol/DHEA-S Ratios in Healthcare Workers and Their Patients During the COVID-19 Pandemic

Sample size: 361 publication Evidence: moderate

Author Information

Author(s): Pividori Isabella, Peric Tanja, Comin Antonella, Cotticelli Alessio, Corazzin Mirco, Prandi Alberto, Mascolo Massimo Domenico, Verduri Alessia

Primary Institution: Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine

Hypothesis

The study aims to examine the hair cortisol/DHEA-S ratios as markers of HPA axis dysregulation in healthcare workers and their patients during the COVID-19 pandemic.

Conclusion

The study found that patients had significantly higher cortisol/DHEA-S ratios than healthcare workers, indicating greater stress and reduced coping ability.

Supporting Evidence

  • Patients had significantly higher cortisol concentrations than healthcare workers.
  • The cortisol/DHEA-S ratio was found to be a useful marker for identifying stress levels.
  • Healthcare workers maintained better hormonal balance compared to patients during the pandemic.
  • The study highlights the importance of monitoring stress in healthcare settings.
  • High cortisol/DHEA-S ratios in patients suggest a greater degree of stress.
  • Lower DHEA-S concentrations were observed in patients compared to healthcare workers.
  • The findings indicate potential risks for mental and physical health in both groups.
  • Further research is needed to explore the long-term implications of these findings.

Takeaway

This study looked at stress hormones in hair to see how stressed healthcare workers and their patients were during the COVID-19 pandemic.

Methodology

The study measured hormone concentrations in hair samples from 200 healthcare workers and 161 patients using a radioimmunoassay.

Limitations

Only a single measure of hair was performed, and additional psychological and lifestyle factors were not assessed.

Participant Demographics

Patients were older (mean age 74) and had chronic illnesses; healthcare workers were younger (mean age 53).

Statistical Information

P-Value

p < 0.001

Statistical Significance

p < 0.001

Digital Object Identifier (DOI)

10.3390/life14121582

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