Second Primary Cancers in Patients with Blood Disorders
Author Information
Author(s): Dong C, Hemminki K
Primary Institution: Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
Hypothesis
What are the common mechanisms leading to second primary malignancies in patients with haematolymphoproliferative disorders?
Conclusion
Patients with haematolymphoproliferative disorders have a significantly increased risk of developing second primary cancers.
Supporting Evidence
- There was over a 3-fold significant increase in various cancers among patients with non-Hodgkin's lymphoma.
- Patients with Hodgkin's disease showed over a 4-fold significant increase in certain cancers.
- A significant increase in skin and nervous system cancers was observed among patients with myeloma and leukaemia.
Takeaway
People who have certain blood cancers are more likely to get other types of cancer later on.
Methodology
The study analyzed data from the Swedish Family-Cancer Database to calculate the standardized incidence ratio of second malignancies.
Participant Demographics
Patients diagnosed with haematolymphoproliferative disorders in Sweden between 1958 and 1996.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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