Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40
2009
Macrophages and Antibody Interactions in Cancer Treatment
Sample size: 10
publication
Evidence: high
Author Information
Author(s): Oflazoglu E, Stone I J, Brown L, Gordon K A, van Rooijen N, Jonas M, Law C-L, Grewal I S, Gerber H-P
Primary Institution: Seattle Genetics Inc.
Hypothesis
Do macrophages contribute to the antitumour activities of the anti-CD40 antibody SGN-40?
Conclusion
Macrophages play a significant role in the antitumour effects of SGN-40, which depend on Fc interactions.
Supporting Evidence
- SGN-40 induces potent antitumour effects on CD40-positive tumour cell lines.
- Macrophages significantly contribute to the therapeutic activities of SGN-40.
- SGN-40G1v1, a mutant form lacking Fc-receptor interactions, showed no therapeutic activity.
Takeaway
This study shows that a special type of immune cell called macrophages helps a cancer treatment work better by eating up cancer cells.
Methodology
The study involved in vitro and in vivo experiments using lymphoma cell lines and mouse models to assess the role of macrophages in the antitumour activity of SGN-40.
Statistical Information
P-Value
0.0016
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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