Fabrication of complex optical phantoms using on-the-fly multi-filament mixing 3-D printing
2024

3-D Printing of Complex Optical Phantoms

Sample size: 16 publication 10 minutes Evidence: moderate

Author Information

Author(s): Ragunathan Rahul, Mireles Miguel, Xu Edward, Lewis Aiden, Vanegas Morris, Fang Qianqian

Primary Institution: Department of Bioengineering, Northeastern University, Boston, USA

Hypothesis

The optical properties of the mixed-filament prints are related to the fractions of each filament type extruded in a given filament mixture.

Conclusion

The study presents a versatile method for fabricating complex heterogeneous optical phantoms using 3-D printing, demonstrating the ability to tune optical properties through filament mixing.

Supporting Evidence

  • The method allows for the creation of phantoms with tunable optical properties relevant to biological tissues.
  • Phantoms were characterized with an average error of 12%-15% compared to predicted values.
  • The approach is low-cost and accessible, utilizing off-the-shelf materials.

Takeaway

This study shows how to make fake body parts that look like real tissues using a special 3-D printer that mixes different colors of plastic.

Methodology

The study utilized a multi-filament 3-D printer to create optical phantoms with varying absorption and scattering properties by mixing different colored PLA filaments.

Potential Biases

Potential variability in optical properties due to differences in filament batches and printer performance.

Limitations

The method may produce minor defects and quality issues, such as stringing artifacts, which could affect the optical properties.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.21203/rs.3.rs-5500473

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