Wound Healing Effects of Allamanda and Laurus Extracts in Rats
Author Information
Author(s): Nayak Shivananda, Nalabothu Poorna, Sandiford Steve, Bhogadi Vidyasagar, Adogwa Andrew
Primary Institution: The University of the West Indies, St. Augustine, Trinidad
Hypothesis
The study aims to evaluate the wound healing activity of Allamanda cathartica and Laurus nobilis extracts in rats.
Conclusion
The study found that Allamanda cathartica has better wound healing activity than Laurus nobilis.
Supporting Evidence
- Allamanda extract significantly increased wound contraction and reduced epithelialisation time.
- Laurus nobilis showed moderate effects compared to the control group.
- Histological studies indicated better collagen formation in Allamanda treated animals.
Takeaway
This study tested two plant extracts on rats to see which one helps wounds heal faster, and found that one plant worked better than the other.
Methodology
The study used excision and incision wound models on Sprague Dawley rats, with groups treated with different extracts for 10 to 14 days.
Potential Biases
Potential bias in the selection of animal models and treatment groups.
Limitations
The study was limited to animal models and may not directly translate to human wound healing.
Participant Demographics
Healthy inbred Sprague Dawley rats of either sex, weighing between 200 g and 220 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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