Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea
2008
Identification of a new virus related to cosaviruses in a child with diarrhea
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Lori R Holtz, Stacy R Finkbeiner, Carl D Kirkwood, David Wang
Primary Institution: Washington University School of Medicine
Hypothesis
Can a novel picornavirus be identified in a child with acute diarrhea using mass sequencing?
Conclusion
A new species of picornavirus, tentatively named Human Cosavirus E1, was identified in a child with acute diarrhea.
Supporting Evidence
- Diarrhea is a leading cause of death worldwide, with many cases of unknown cause.
- Mass sequencing was used to identify a novel virus in a stool sample.
- The identified virus shares limited identity with known picornaviruses.
Takeaway
Scientists found a new virus in a child's poop that might be related to other viruses that cause diarrhea.
Methodology
Mass sequencing, RT-PCR, 5' RACE, and 3' RACE were used to analyze a stool sample.
Limitations
The clinical role of HCoSV-E1 in diarrhea or other diseases is unknown.
Participant Demographics
A stool sample from a child with acute diarrhea.
Digital Object Identifier (DOI)
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