Role of p16/MTS1, cyclin D1 and RB in oral cancer
Author Information
Author(s): Sartor M, Steingrimsdottir H, Elamin F, Gäken J, Warnakulasuriya S, Partridge M, Thakker N, Johnson N W, Tavassoli M
Primary Institution: King's College School of Medicine and Dentistry
Hypothesis
The study investigates the alterations of p16/MTS1, cyclin D1, and RB in primary oral cancer and oral cancer cell lines.
Conclusion
Abnormalities of the RB pathway are a common mechanism of oral carcinogenesis.
Supporting Evidence
- p16/MTS1 gene alterations were found in 19% of primary tumors and 75% of cell lines.
- 69% of OSCCs showed absence of p16/MTS1 expression.
- 56% of OSCCs expressed pRB, but only 78% of those were active.
- 41% of OSCCs overexpressed cyclin D1.
Takeaway
The study found that many oral cancer cells have changes in important genes that help control cell growth, which can lead to cancer.
Methodology
The study screened 26 oral squamous cell carcinomas, nine premalignant, and three normal oral tissue samples for mutations in the p16/MTS1 gene and analyzed the expression of p16/MTS1, cyclin D1, and pRB.
Digital Object Identifier (DOI)
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