Key Proteomic Signatures of Delirium
Author Information
Author(s): Mosharaf Md Parvez, Alam Khorshed, Gow Jeff, Mahumud Rashidul Alam
Primary Institution: University of Southern Queensland
Hypothesis
This study aimed to accumulate and identify the key common proteomic signatures associated with delirium.
Conclusion
The review identified 13 key proteins significantly associated with delirium, highlighting the role of cytokines and inflammatory proteins.
Supporting Evidence
- Delirium affects up to 50% of hospitalized elderly patients.
- IL-6 was the most reported protein associated with delirium.
- Most included studies were of moderate to high quality.
Takeaway
Delirium is a serious condition that can be linked to certain proteins in the body, and understanding these proteins can help doctors treat it better.
Methodology
A systematic literature review was conducted, following PRISMA guidelines, to identify studies on delirium proteomic biomarkers published from 2000 to 2023.
Potential Biases
The included studies varied in quality and methodology, which may introduce bias in the findings.
Limitations
The review did not include studies on Alzheimer’s disease and dementia, and may have missed relevant studies outside the selected databases.
Participant Demographics
Most studies included critically ill patients from various countries, primarily the USA and China.
Digital Object Identifier (DOI)
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