Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor
2001
Laminin-1 and Multiple Myeloma Cell Migration
publication
Evidence: moderate
Author Information
Author(s): Vande Broek I, Vanderkerken K, De Greef C, Asosingh K, Straetmans N, Van Camp B, Van Riet I
Primary Institution: Free University Brussels (VUB)
Hypothesis
Does laminin-1 induce migration of multiple myeloma cells through the 67 kD laminin receptor?
Conclusion
Laminin-1 acts as a chemoattractant for multiple myeloma cells by interacting with the 67 kD laminin receptor.
Supporting Evidence
- Human multiple myeloma cell lines express the 67LR.
- Laminin-1 stimulated the migration of multiple myeloma cells in vitro.
- The migration was partially blocked by a synthetic nonapeptide derived from laminin-1.
Takeaway
Laminin-1 helps multiple myeloma cells move around by sticking to a special receptor on their surface.
Methodology
The study involved in vitro migration assays and in vivo models to assess the role of laminin-1 and the 67LR in multiple myeloma cell migration.
Participant Demographics
The study involved human multiple myeloma cell lines and murine models.
Digital Object Identifier (DOI)
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