Role of TGF-α in Gastro-Oesophageal Junction Adenocarcinoma
Author Information
Author(s): D'Errico A, Barozzi C, Fiorentino M, Carella R, Simone M Di, Ferruzzi L, Mattioli S, Grigioni W F
Primary Institution: Pathology Division of the ‘F Addarii’ Institute, Department of Oncology, University School of Medicine, Bologna, Italy
Hypothesis
The study investigates the role of transforming growth factor alpha (TGF-α) in the biological behavior of gastro-oesophageal junction adenocarcinomas.
Conclusion
TGF-α expression is associated with tumor progression and lymph node metastasis in gastro-oesophageal junction adenocarcinomas.
Supporting Evidence
- TGF-α mRNA and protein were detectable in 56% and 64% of cases respectively.
- TGF-α protein expression was significantly associated with tumor progression.
- TGF-α expression was associated with lymph node metastasis.
Takeaway
This study found that a protein called TGF-α is present in many cancer cells and might help doctors understand how aggressive the cancer is.
Methodology
The study evaluated TGF-α expression and p53 overexpression in resected type II GEJ adenocarcinomas using immunohistochemistry and in situ hybridization.
Statistical Information
P-Value
P = 0.025
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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