Review of Primary Hyperparathyroidism in India
Author Information
Author(s): P. V. Pradeep, Jayashree B. Mishra, Mishra Anjali, Mishra S. K.
Primary Institution: Narayana Medical College and Superspeciality Hospitals, Nellore, Andhra Pradesh, India
Hypothesis
What is the current status and trends of primary hyperparathyroidism (PHPT) in India compared to Western countries?
Conclusion
Most patients in India present with symptomatic primary hyperparathyroidism, and there is a need for better screening to detect asymptomatic cases.
Supporting Evidence
- 77% of patients had bone disease, and 36% had renal disease.
- Mean calcium and parathyroid hormone levels were high, while Vitamin D levels were low.
- Postoperative hungry bone syndrome was common, affecting 24% to 82% of cases.
Takeaway
In India, many people with primary hyperparathyroidism have symptoms, unlike in Western countries where many cases are found early and are asymptomatic.
Methodology
Systematic review of literature on primary hyperparathyroidism in India from 1980 to 2010.
Potential Biases
Potential bias due to the predominance of case reports and small series in the literature.
Limitations
Lack of uniformity in data across studies and limited access to medical treatment in rural areas.
Participant Demographics
Females were more commonly affected (1.7:1, F:M), with 71.5% of cases under 40 years of age.
Statistical Information
P-Value
p<0.001 for differences in biochemical parameters compared to the USA.
Digital Object Identifier (DOI)
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