Nasal Absorption of Paeonol in Rats
Author Information
Author(s): Chen Xiaolan, Lu Yang, Du Shouying, Xu Bing, Wang Shan, Zhai Yongsong, Song Xiao, Li Pengyue
Primary Institution: Beijing University of Chinese Medicine
Hypothesis
The study aims to investigate the in situ and in vivo nasal absorption of paeonol in rats.
Conclusion
Paeonol can be absorbed quickly and effectively through intranasal administration in rats.
Supporting Evidence
- Paeonol was better absorbed in acidic solutions than in neutral or alkaline solutions.
- The bioavailability of paeonol was 52.37% for intranasal administration, compared to 15.81% for intragastric administration.
- The absorption rate constant increased with an increase in perfusion speed.
Takeaway
This study shows that giving paeonol through the nose works better than taking it by mouth.
Methodology
A novel single pass in situ nasal perfusion technique was used to study the nasal absorption of paeonol in rats, comparing pharmacokinetics of intranasal, intragastric, and intravenous administration.
Limitations
The study may not fully represent human responses to nasal administration of paeonol.
Participant Demographics
Male Sprague Dawley rats, weighing 230-250 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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