Inhibitory effect of esculentoside A on prostaglandin E2 production from murine peritoneal macrophages and rabbit synovial cells in vitro
1997
Inhibitory Effect of Esculentoside A on Prostaglandin E2 Production
Sample size: 4
publication
Evidence: moderate
Author Information
Author(s): H-B. Wang, J. Fang, Q-Y. Zheng
Primary Institution: Second Military Medical University
Hypothesis
Does esculentoside A inhibit prostaglandin E2 production from macrophages and synovial cells?
Conclusion
Esculentoside A significantly inhibits prostaglandin E2 production from both murine macrophages and rabbit synovial cells.
Supporting Evidence
- Esculentoside A inhibited prostaglandin E2 production from unstimulated macrophages.
- In LPS and A23187 treated groups, esculentoside A significantly inhibited prostaglandin E2 production.
- EsA had no significant effect on the total release of arachidonic acid from macrophages.
Takeaway
Esculentoside A is a natural compound that helps reduce a substance in the body that causes inflammation.
Methodology
The study used murine macrophages and rabbit synovial cells to test the effect of esculentoside A on prostaglandin E2 production.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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