Human Cytomegalovirus Co-Infection in Egyptian Chronic HCV Patients
Author Information
Author(s): Tabll Ashraf, Shoman Sahar, Ghanem Hussam, Nabil Mohamed, El Din Noha G Bader, El Awady Mostafa K
Primary Institution: National Research Center, Giza, Egypt
Hypothesis
What is the incidence of HCMV infection in HCV patients who either spontaneously cleared the virus or progressed to chronic HCV infection?
Conclusion
Chronic HCV patients co-infected with HCMV are at high risk for liver disease progression and should be monitored for long-term outcomes.
Supporting Evidence
- 63% of the cases were positive for HCV-RNA.
- 87% of HCV RNA positive patients had positive HCMV IgG antibodies.
- 38% of chronic HCV patients had detectable HCMV DNA.
Takeaway
This study found that many people with chronic hepatitis C also have a virus called HCMV, which can make their liver problems worse.
Methodology
The study involved 84 subjects who were tested for HCV and HCMV using PCR and serological methods.
Participant Demographics
48 females and 36 males, aged 18-64 years (mean age 37.62 ± 10.03 years).
Statistical Information
P-Value
< 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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