CENP-H Expression in Esophageal Carcinoma
Author Information
Author(s): Guo Xian-Zhi, Zhang Ge, Wang Jun-Ye, Liu Wan-Li, Wang Fang, Dong Ju-Qin, Xu Li-Hua, Cao Jing-Yan, Song Li-Bing, Zeng Mu-Sheng
Primary Institution: Sun Yat-sen University Cancer Center
Hypothesis
The study aims to clarify the expression of Centromere protein H (CENP-H) in esophageal carcinoma and its correlation with clinicopathological features.
Conclusion
CENP-H protein is a valuable marker of esophageal carcinoma progression and may serve as a prognostic marker for patients.
Supporting Evidence
- CENP-H was expressed in 127 of 171 esophageal squamous cell carcinoma cases (74.3%).
- Patients with lower CENP-H expression had longer overall survival time than those with higher expression.
- CENP-H expression was significantly correlated with clinical stage and T classification.
Takeaway
CENP-H is a protein that helps in cell division, and higher levels of it in esophageal cancer patients are linked to worse outcomes.
Methodology
The study examined CENP-H expression in esophageal carcinoma tissues and cell lines using RT-PCR, Western blot analysis, and immunohistochemistry.
Potential Biases
Potential bias in patient selection and the retrospective nature of the study may affect the results.
Limitations
The study primarily focused on esophageal squamous cell carcinoma, limiting the generalizability of findings to other types of esophageal cancer.
Participant Demographics
The study included 171 esophageal squamous cell carcinoma patients, with 129 males and 42 females, aged 33 to 82 years.
Statistical Information
P-Value
P = 0.013 for gender, P = 0.023 for stage, P = 0.019 for T classification
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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