Ancestral European roots of Helicobacter pylori in India
Author Information
Author(s): Devi S Manjulata, Ahmed Irshad, Francalacci Paolo, Hussain M Abid, Akhter Yusuf, Alvi Ayesha, Sechi Leonardo A, Mégraud Francis, Ahmed Niyaz
Primary Institution: Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
Hypothesis
How different waves of human migrations in South Asia shaped the population structure of H. pylori.
Conclusion
H. pylori strains in India share ancestral origins with their European counterparts.
Supporting Evidence
- All isolates analyzed revealed European ancestry and belonged to H. pylori sub-population, hpEurope.
- The cagPAI harbored by Indian strains revealed European features upon PCR based analysis.
- Seventeen Ladakhi isolates clustered tightly to form a separate branch, hpAsia2.
Takeaway
Scientists studied bacteria from Indian people to see where they came from and found that they are related to European bacteria.
Methodology
Multilocus sequence typing (MLST) of 7 housekeeping genes and phylogeographic analysis of haplotypes.
Limitations
The study did not document the presence of other H. pylori populations and sub-populations in the isolates analyzed.
Participant Demographics
Indian isolates from culturally and linguistically diverse ethnic Indians.
Digital Object Identifier (DOI)
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