Influence of Genetic Variants on Global DNA Methylation
Author Information
Author(s): Naila Francis Paulo de Oliveira, Darlene Camati Persuhn, Maria Cristina Leme Godoy
Primary Institution: Federal University of Paraíba—UFPB, João Pessoa, Brazil
Hypothesis
Can genetic polymorphisms in MTHFR and DNMT genes influence global DNA methylation profiles?
Conclusion
Polymorphisms in the MTHFR and DNMT genes may influence the global DNA methylation profile in various health contexts.
Supporting Evidence
- Polymorphisms in the MTHFR and DNMT genes were associated with global DNA methylation levels.
- Different studies showed varying results based on the context of the genetic variants.
- Some studies indicated that the same polymorphism could be linked to both higher and lower methylation levels.
Takeaway
Some genes can change how our DNA is marked, which can affect our health. This study looks at how certain gene changes might change these marks.
Methodology
A narrative review of studies published in the last 15 years.
Potential Biases
Potential biases due to the variability in sample populations and methodologies used across studies.
Limitations
The review is limited by the variability in study designs and the context-dependent nature of the associations.
Digital Object Identifier (DOI)
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