Probiotic Lactobacillus Improves Immune Response Against Salmonella in Mice
Author Information
Author(s): Natalia A Castillo, Gabriela Perdigón, Alejandra de Moreno de LeBlanc
Primary Institution: Centro de Referencia para Lactobacilos (CERELA-CONICET)
Hypothesis
How does the probiotic Lactobacillus casei CRL 431 affect cytokine production and TLR expression in response to Salmonella infection?
Conclusion
The continuous administration of L. casei CRL 431 enhances the immune response against Salmonella Typhimurium by modulating cytokine profiles and TLR expression.
Supporting Evidence
- Probiotic administration increased TLR2, TLR4, and TLR9 expression in healthy mice.
- Continuous probiotic administration decreased TNFα and increased IFNγ, IL-6, and IL-10 production post-infection.
- Probiotic treatment maintained the immune system's alert state before and after Salmonella infection.
Takeaway
Giving mice a probiotic called Lactobacillus helps their bodies fight off a germ called Salmonella better.
Methodology
BALB/c mice were divided into groups receiving L. casei CRL 431 before and after Salmonella infection, and cytokine levels were measured in Peyer's patches and intestinal fluid.
Limitations
The study was conducted in a mouse model, which may not fully replicate human responses.
Participant Demographics
Five-week-old BALB/c mice, both male and female.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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