Nipple aspirate cytology and pathologic parameters predict residual cancer and nodal involvement after excisional breast biopsy
2001
Predicting Breast Cancer Residuals and Lymph Node Involvement
publication
Evidence: high
Author Information
Author(s): Sauter E R, Ehya H, Mammen A, Klein Gary
Primary Institution: Thomas Jefferson University
Hypothesis
Pathologic factors combined with nipple aspirate cytology can accurately predict the presence of residual cancer and lymph node spread after excisional breast biopsy.
Conclusion
The combined model using nipple aspirate cytology and pathologic parameters was highly effective in predicting residual cancer and lymph node involvement.
Supporting Evidence
- The combined logistic regression model predicted residual cancer with 94% accuracy.
- Normal nipple aspirate cytology was 92% sensitive in predicting residual cancer.
- Tumor size and nipple aspirate cytology were effective in predicting lymph node involvement.
Takeaway
Doctors can use nipple fluid tests and other factors to better understand if breast cancer remains after surgery.
Methodology
The study evaluated nipple aspirate cytology and various pathologic parameters using logistic regression to predict residual cancer and lymph node involvement.
Digital Object Identifier (DOI)
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