Gene Polymorphism and Chronic Periodontitis
Author Information
Author(s): Ankang Hu, Xin Wang, Lisi Ai, Kun Liu, Lingxue Kong
Primary Institution: Jinan Stomatological Hospital, Jinan, China
Hypothesis
This study aimed to explore the correlation between the Matrix Metalloproteinase-3 (MMP-3) 1171 5A/6A gene polymorphism and susceptibility to Chronic Periodontitis (CP).
Conclusion
While no significant correlation was found in the overall population, the stratified analysis revealed nuanced relationships contingent on genotyping methods and smoking habits.
Supporting Evidence
- Five studies were included in the meta-analysis, published between 2004 and 2019.
- No significant association was observed between MMP-3 gene polymorphism and CP susceptibility across all subjects.
- Subgroup analysis revealed significant differences based on genotyping methods and smoking habits.
- The 5A mutation increased susceptibility to CP among smokers but decreased it among non-smokers.
Takeaway
This study looked at how a specific gene might affect the risk of gum disease, finding that it can change depending on how you test for it and whether someone smokes.
Methodology
A systematic review and meta-analysis were conducted following PRISMA guidelines, analyzing case-control studies on MMP-3 gene polymorphism and CP.
Potential Biases
Potential publication bias due to selective reporting and unpublished studies.
Limitations
The study had a relatively small sample size and lacked raw data from individual studies, limiting control over potential confounders.
Participant Demographics
Studies included participants from Japan, Brazil, China, and India, with varying case and control group sizes.
Statistical Information
P-Value
<0.001
Confidence Interval
95%CI (1.02~1.23)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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