The surface protein Shr of Streptococcus pyogenes binds heme and transfers it to the streptococcal heme-binding protein Shp
2008
How a Protein in Streptococcus pyogenes Binds and Transfers Heme
publication
Evidence: moderate
Author Information
Author(s): Zhu Hui, Liu Mengyao, Lei Benfang
Primary Institution: Montana State University
Hypothesis
Does the surface protein Shr bind heme and serve as a heme source for Shp?
Conclusion
The study shows that Shr binds heme and transfers it to Shp, but not to HtsA, indicating its role in heme acquisition in S. pyogenes.
Supporting Evidence
- Shr binds heme and can acquire it from E. coli hemoproteins.
- Shr transfers heme to Shp more efficiently than to HtsA.
- Shr does not directly acquire heme from human methemoglobin.
Takeaway
The protein Shr helps the bacteria get iron from heme by grabbing it and passing it to another protein called Shp.
Methodology
Recombinant Shr protein was prepared and its ability to bind and transfer heme was analyzed through various biochemical assays.
Digital Object Identifier (DOI)
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