Eicosanoid and Cytokine Levels in Plasma During Mesenteric Infarction
Author Information
Author(s): N. Nathan, Y. Denizot, P. Feiss
Primary Institution: CHU Dupuytren, Limoges, France
Hypothesis
What are the eicosanoid and cytokine levels in patients with mesenteric infarction before the development of multiple organ failure?
Conclusion
High levels of IL-6, IL-8, and 6-keto-PGF1a were found in patients with mesenteric infarction, suggesting their role in the development of multiple organ failure.
Supporting Evidence
- High plasma levels of IL-6 and IL-8 were found in the three patients.
- TNFa was not detectable in the patients, suggesting it was not clinically relevant.
- The study confirms experimental data questioning the role of TNFa in inflammatory reactions.
Takeaway
Doctors studied the blood of three patients who had a serious stomach problem to see what chemicals were in their blood before they got really sick.
Methodology
Blood samples were taken from patients with mesenteric infarction and compared to a control group of atherosclerotic patients.
Limitations
The small number of subjects due to difficulties in obtaining blood samples before multiple organ failure occurred.
Participant Demographics
Three patients with mesenteric infarction and ten control patients with severe atherosclerotic disease.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website