Fetal Cells in Breast Cancer During Pregnancy
Author Information
Author(s): Dubernard Gil, Aractingi Sélim, Oster Michel, Rouzier Roman, Mathieu Marie-Christine, Uzan Serge, Khosrotehrani Kiarash
Primary Institution: Université Pierre et Marie Curie, Paris VI
Hypothesis
Are fetal derived cells present in breast carcinoma associated with pregnancy?
Conclusion
Fetal derived cells are frequently found in the stroma of breast carcinomas associated with pregnancy.
Supporting Evidence
- Fetal cells were present in 9 out of 10 breast carcinomas.
- The mean number of fetal cells per million maternal cells was 36 in breast cancers.
- No fetal cells were found in benign mammary lesions.
Takeaway
When women have breast cancer during pregnancy, they often have cells from their babies in the tumors. These baby cells might help the cancer grow.
Methodology
Fluorescence in situ hybridization (FISH) was used to detect fetal cells in breast carcinoma tissues from pregnant women.
Potential Biases
Potential bias due to the retrospective nature of the study and selection criteria.
Limitations
The study had a small sample size and was limited to specific institutions.
Participant Demographics
Women diagnosed with breast carcinoma during pregnancy or within 6 months postpartum, with a mean age of 36 years.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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