Re-surgery and re-irradiation for recurrent breast cancer
Author Information
Author(s): Müller Arndt-Christian, Eckert Franziska, Heinrich Vanessa, Bamberg Michael, Brucker Sara, Hehr Thomas
Primary Institution: Eberhard-Karls-University
Hypothesis
The efficacy and toxicity of a second curative radiotherapy series was investigated in cases of recurrent breast cancer.
Conclusion
Repeat radiotherapy for recurrent breast cancer with total radiation doses of 60 Gy and the addition of hyperthermia was feasible, with acceptable late morbidity and improved prognosis.
Supporting Evidence
- The estimated 5-year local control rate reached 62%.
- The estimated 5-year overall survival rate was 59%.
- Significantly inferior survival was associated with recurrence within two years.
- Concurrent hyperthermia was performed in 29 patients.
Takeaway
This study looked at how well repeat radiation therapy works for women with breast cancer that came back after treatment. It found that it can be safe and help many women live longer.
Methodology
The study involved 42 women treated with resection and re-irradiation for recurrent breast cancer, with concurrent hyperthermia in some cases.
Potential Biases
Potential biases include selection bias due to the retrospective nature and the specific patient population studied.
Limitations
The study is retrospective and involved a small sample size, which may limit the generalizability of the findings.
Participant Demographics
Median age was 57 years, with a range of 33-75 years.
Statistical Information
P-Value
p = 0.03
Confidence Interval
CI: 46-71 months
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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