DARPP-32 Expression in Oesophageal Cancer
Author Information
Author(s): Ebihara Y, Miyamoto M, Fukunaga A, Kato K, Shichinohe T, Kawarada Y, Kurokawa T, Cho Y, Murakami S, Uehara H, Kaneko H, Hashimoto H, Murakami Y, Itoh T, Okushiba S, Kondo S, Katoh H
Primary Institution: Hokkaido University Graduate School of Medicine
Hypothesis
Does DARPP-32 expression arise after a phase of dysplasia in oesophageal squamous cell carcinoma?
Conclusion
DARPP-32 expression arises after a phase of dysplasia in OSCC, and DARPP-32-positive tumours have a less aggressive character than those that are not.
Supporting Evidence
- DARPP-32 was expressed in 30.3% of OSCC specimens.
- The study found an inverse relationship between DARPP-32 expression and pathologic stage.
- Patients with DARPP-32-positive tumours had a better prognosis than those with negative tumours.
Takeaway
This study found that a protein called DARPP-32 shows up in oesophageal cancer after some early changes, and cancers with this protein are less aggressive.
Methodology
The study examined DARPP-32 expression in OSCC cell lines and surgical specimens using RT-PCR and immunohistochemistry.
Limitations
The study was retrospective and excluded patients with in-hospital death.
Participant Demographics
105 males and 17 females, median age 62.3 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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