Genetic Variants in LAG3 and CD4 Genes and Essential Tremor Risk
Author Information
Author(s): Agúndez José A. G., Macías Yolanda, Alonso-Navarro Hortensia, García-Martín Elena, Álvarez Ignacio, Pastor Pau, Benito-León Julián, López-Alburquerque Tomás, Jiménez-Jiménez Félix Javier
Primary Institution: University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura
Hypothesis
Is there an association between common variants in the LAG3/CD4 genes and the risk for essential tremor?
Conclusion
The study found no major association between the gene variants studied and the risk of developing essential tremor, except for a slight decrease in risk in male patients carrying the LAG3 rs870849C variant.
Supporting Evidence
- 267 patients with familial essential tremor were genotyped.
- 270 age- and sex-matched controls were used for comparison.
- Significant decrease in LAG3 rs870849 C/C genotype frequency was found in men with essential tremor compared to controls.
Takeaway
This study looked at whether certain genes are linked to a shaking condition called essential tremor, but found that they probably aren't, especially for most people.
Methodology
The study genotyped 267 patients with familial essential tremor and 270 age- and sex-matched controls using TaqMan assays for specific gene variants.
Potential Biases
Potential bias due to the control group possibly developing essential tremor in the future.
Limitations
The study had a low sample size and controls were not matched by age.
Participant Demographics
267 patients with familial essential tremor (130 men, 137 women) and 270 gender-matched controls (130 men, 140 women), all of Caucasian Spanish origin.
Statistical Information
P-Value
0.06
Confidence Interval
95% CI not specified
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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