Increased Resistin mRNA Expression in Type 2 Diabetic Women
Author Information
Author(s): Panayoula C. Tsiotra, Constantine Tsigos, Eleni Anastasiou, Eleni Yfanti, Eleni Boutati, Emmanouil Souvatzoglou, Ioannis Kyrou, Sotirios A. Raptis
Primary Institution: Hellenic National Center for the Research, Prevention and Treatment of Diabetes Mellitus and Its Complications
Hypothesis
The study aims to examine whether resistin mRNA expression in human peripheral mononuclear cells and its corresponding plasma levels are altered in type 2 diabetes.
Conclusion
Resistin mRNA expression is increased in peripheral mononuclear cells from type 2 diabetic women, along with elevated levels of inflammatory cytokines.
Supporting Evidence
- Resistin mRNA levels were higher in type 2 diabetic women compared to healthy controls.
- Mononuclear mRNA levels of IL-1β, TNF-α, and IL-6 were significantly higher in diabetic women.
- Plasma resistin levels correlated with BMI and waist circumference.
Takeaway
This study found that women with type 2 diabetes have higher levels of a substance called resistin in their blood cells, which might be linked to inflammation and health risks.
Methodology
The study involved 48 premenopausal women, 22 with type 2 diabetes and 26 healthy controls, measuring resistin and inflammatory cytokine mRNA levels in peripheral mononuclear cells.
Limitations
The small sample size may limit the generalizability of the findings.
Participant Demographics
All participants were premenopausal women aged between 21 and 49 years.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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