Effects of Plasma-Rich Growth Factors on Skin Inflammation
Author Information
Author(s): Muacevic Alexander, Adler John R, Anitua Eduardo, Tierno Roberto, Martínez de Lagrán Zuriñe, Alkhraisat Mohammad H
Primary Institution: University Institute for Regenerative Medicine and Oral Implantology (UIRMI), Vitoria, ESP
Hypothesis
The study aims to evaluate the biological effect of plasma rich in growth factors (PRGFs) obtained from patients with different inflammatory skin conditions using a cell-based in vitro model of skin inflammation.
Conclusion
PRGF derived from pathological patients contains autoimmune components that could compromise its effectiveness as a therapy for treating individuals with chronic inflammatory disorders.
Supporting Evidence
- PRGF has shown potential benefits in patients with chronic skin disorders due to its anti-inflammatory effect.
- Heat inactivation significantly promoted cell proliferation in epidermal keratinocytes.
- Leukocyte exclusion improved cell behavior in terms of migration.
- PRGF formulations improved cell viability, proliferation, and migration in inflamed cell cultures.
Takeaway
This study looks at how a special treatment from blood can help heal skin problems, but it found that some patients' blood might not work as well because of certain harmful components.
Methodology
The study used cell-based in vitro models with human dermal fibroblasts and human epidermal keratinocytes to assess the effects of PRGF formulations on cell viability, proliferation, and migration.
Potential Biases
The presence of confounding variables, particularly regarding the effects of biological medications or anti-inflammatory drugs on PRGF composition and bioactivity.
Limitations
The study had a small number of participants and variability in medication use patterns, which may affect the results.
Participant Demographics
Participants included 20 individuals: 5 healthy donors, 5 with atopic dermatitis, 5 with psoriasis, and 5 with lichen sclerosus.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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