Pregnancy Outcomes After IMSI vs. ICSI in Women with Repeated Implantation Failures
Author Information
Author(s): João Batista Oliveira, Mario Cavagna, Claudia G. Petersen, Ana L. Mauri, Fabiana C. Massaro, Liliane F. Silva, Ricardo L. Baruffi, Jose G. Franco Jr.
Primary Institution: Department of Gynecology and Obstetrics, Botucatu Medical School Sao Paulo State University - UNESP, Botucatu, Brazil
Hypothesis
Does intracytoplasmic morphologically selected sperm injection (IMSI) improve pregnancy outcomes compared to conventional intracytoplasmic sperm injection (ICSI) in couples with repeated implantation failures?
Conclusion
IMSI does not significantly improve clinical outcomes compared to ICSI, but shows trends for lower miscarriage rates and higher ongoing pregnancy and live birth rates.
Supporting Evidence
- IMSI showed a trend towards lower miscarriage rates compared to ICSI.
- Ongoing pregnancy rates were nearly doubled in the IMSI group.
- Live birth rates were also higher in the IMSI group compared to ICSI.
Takeaway
This study looked at two ways to help couples get pregnant after trying many times. One method didn't work better than the other, but it did show some signs of being a little better.
Methodology
200 couples with at least two prior unsuccessful ICSI cycles were divided into two groups: 100 underwent IMSI and 100 underwent conventional ICSI.
Limitations
The study may not have had enough participants to detect significant differences in outcomes.
Participant Demographics
Couples with repeated implantation failures, matched by female age.
Statistical Information
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
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