Effects of Bisphenol A on Mouse Fertility
Author Information
Author(s): Cabaton Nicolas J., Wadia Perinaaz R., Rubin Beverly S., Zalko Daniel, Schaeberle Cheryl M., Askenase Michael H., Gadbois Jennifer L., Tharp Andrew P., Whitt Gregory S., Sonnenschein Carlos, Soto Ana M.
Primary Institution: Tufts University School of Medicine
Hypothesis
Perinatal exposure to BPA impairs the reproductive function of exposed females.
Conclusion
Perinatal exposure to BPA leads to a dose-dependent decline in the reproductive capacity of female mice.
Supporting Evidence
- BPA exposure resulted in a decrease in the cumulative number of pups born to treated mice.
- The BPA 25 μg/kg group showed a significant decrease in the number of pregnancies.
- The cumulative number of pups born to BPA 25 ng/kg and BPA 25 μg/kg dams was significantly lower than controls.
Takeaway
If baby mice are exposed to a chemical called BPA while their mothers are pregnant, they might have trouble having babies when they grow up.
Methodology
Female CD-1 mice were exposed to different doses of BPA during pregnancy and lactation, then mated with proven breeder males for 32 weeks to assess fertility and fecundity.
Limitations
The forced breeding protocol does not allow for detailed evaluation of fertilization, implantation, and pregnancy maintenance.
Participant Demographics
CD-1 female mice and proven breeder male mice.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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