Bioadhesive Films for Domperidone Delivery
Author Information
Author(s): M. Singh, A.K. Tiwary, G. Kaur
Primary Institution: Punjabi University
Hypothesis
Can interpolymer complexes of cationic guar gum and xanthan gum be used to formulate effective bioadhesive films for domperidone?
Conclusion
The study found that interpolymer complex films of xanthan gum and cationic guar gum can effectively enhance the bioavailability of domperidone compared to conventional tablets.
Supporting Evidence
- The films released 98% of domperidone in 8 hours.
- The bioadhesive films showed a residence time of approximately 8 hours.
- The formulation with an 80:20 ratio of CGG:XG had the best bioadhesive strength.
Takeaway
The researchers made special films that stick to the inside of your mouth to help medicine work better and last longer.
Methodology
The study involved preparing interpolymer complex films, testing their bioadhesive strength, and conducting in vitro drug release and pharmacokinetic studies in rabbits.
Limitations
The study did not evaluate the films containing only CGG or XG due to their extreme pH levels.
Participant Demographics
Rabbits weighing 3-4 kg were used for pharmacokinetic studies.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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