Effects of Andrographis paniculata Extract on Inflammation in Mice
Author Information
Author(s): Chao Wen-Wan, Kuo Yueh-Hsiung, Hsieh Shie-Liang, Lin Bi-Fong
Primary Institution: National Taiwan University
Hypothesis
The study investigates the anti-inflammatory effects of ethyl acetate extract from Andrographis paniculata.
Conclusion
The extract significantly inhibits the production of inflammatory mediators and improves survival rates in mice subjected to acute inflammation.
Supporting Evidence
- AP extract significantly inhibited NF-κB luciferase activity in macrophages.
- Survival rates in mice treated with AP extract were significantly higher than the control group.
- AP extract reduced levels of TNF-α, IL-6, and MIP-2 in serum and peritoneal macrophages.
Takeaway
This study shows that a plant extract can help reduce inflammation and make sick mice feel better.
Methodology
The study involved in vitro assays on macrophages and in vivo tests on BALB/c mice, measuring inflammatory mediators and survival rates.
Limitations
The study did not explore the effects of higher doses of the extract, which showed lower survival rates.
Participant Demographics
Female BALB/c mice, aged 8 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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