Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract
2011
Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract
publication
Evidence: moderate
Author Information
Author(s): Sridar Chittur, Brian Parr, Geno Marcovici
Primary Institution: State University of New York (SUNY)
Hypothesis
Can a composition containing LSESr, carnitine, and thioctic acid alter the expression of inflammatory markers in keratinocytes?
Conclusion
The composition effectively suppressed inflammatory gene expression in keratinocytes without harming cell viability.
Supporting Evidence
- The composition suppressed LPS-activated gene expression of chemokines CCL17, CXCL6, and LTB(4).
- Statistically significant fold changes were observed in inflammatory markers.
- The study used a well-validated in vitro assay representative of hair follicle keratinocytes.
Takeaway
This study found that a special mixture can help reduce inflammation in skin cells, which might help with hair loss problems.
Methodology
The study used cultured human keratinocyte cells and measured changes in gene expression after treatment with the test compound and LPS.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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