Sialyl Tn as a prognostic marker in epithelial ovarian cancer
1992
Sialyl Tn as a Prognostic Marker in Ovarian Cancer
Sample size: 89
publication
Evidence: moderate
Author Information
Author(s): H. Kobayashi, T. Terao, Y. Kawashima
Primary Institution: Hamamatsu University School of Medicine
Hypothesis
Does circulating serum levels of STN antigen influence the prognosis of patients with ovarian cancer?
Conclusion
Patients with STN-positive tumors have significantly lower survival rates compared to those with STN-negative tumors.
Supporting Evidence
- 5-year survival rate for STN-positive patients was 11%, while it was 77% for STN-negative patients.
- STN-positive patients had a shorter progression-free interval compared to STN-negative patients.
- Multivariate analysis identified STN positivity as a significant negative predictor of survival.
Takeaway
This study found that a specific marker in the blood can help predict how well patients with ovarian cancer will do.
Methodology
Serum samples were collected from patients and analyzed for STN antigen levels using a competitive immunoradiometric assay.
Participant Demographics
Patients with histologically proven epithelial ovarian cancer, staged according to FIGO classification.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website