Genetic Variants in ACE2 and COVID-19 Test Positivity
Author Information
Author(s): Jiménez-Gil Karina, Cerón-Albarrán Jorge Alberto, Gonzalez-Fernandez Melissa Daniella, Sevilla-Montoya Rosalba, Hidalgo-Bravo Alberto, Angeles-Martínez Javier, Montes-Herrera Daniel, Villavicencio-Carrisoza Oscar, García-Romero Carmen Selene, Muñoz-Medina José Esteban, Monroy-Muñoz Irma Eloisa
Primary Institution: National Institute of Perinatology
Hypothesis
The study aims to analyze the association of genetic variants in ACE2 with persistent SARS-CoV-2 infection in healthcare professionals.
Conclusion
The study found that certain ACE2 genetic variants are associated with a higher risk of persistent SARS-CoV-2 positivity in healthcare workers.
Supporting Evidence
- Four ACE2 variants were associated with persistent SARS-CoV-2 qPCR positivity.
- Three variants were linked to increased risk in women and men.
- The study highlights the need for genetic screening in healthcare professionals.
Takeaway
Some people have special genes that make them more likely to keep testing positive for COVID-19, even after they feel better.
Methodology
A case-control study was conducted with 151 healthcare workers who tested positive for SARS-CoV-2, analyzing ACE2 genetic variants through Sanger sequencing.
Potential Biases
Potential bias due to convenience sampling and lack of healthy control samples.
Limitations
The study did not evaluate individual symptoms or the impact of comorbidities on the results.
Participant Demographics
151 healthcare workers, including 67 persistent and 75 non-persistent cases, with a majority being female.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website