Hag Protein in Moraxella catarrhalis and Its Role in Cell Adhesion
Author Information
Author(s): Brian Bullard, Serena Lipski, Eric R. Lafontaine
Primary Institution: University of Toledo Health Sciences Campus
Hypothesis
What role does the Hag protein play in the adherence of Moraxella catarrhalis to human epithelial cells?
Conclusion
Hag is a key adherence factor for human cells relevant to pathogenesis by Moraxella catarrhalis, and its binding properties differ from other related proteins.
Supporting Evidence
- Hag expression is important for the adherence of M. catarrhalis to NCIH292 and Chang cells.
- Hag directly mediates adherence to NCIH292 lung cells and collagen.
- Residues 385–705 of Hag are important for adherence to epithelial cells.
Takeaway
The Hag protein helps the bacteria stick to human cells, which is important for causing infections.
Methodology
The study involved testing the adherence of M. catarrhalis strains and recombinant E. coli expressing Hag to various human epithelial cell lines.
Limitations
The study did not explore the role of other potential adhesins in the native M. catarrhalis background.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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