How Alternative Splicing Affects Epigenetic Regulators
Author Information
Author(s): Lois Sergio, Blanco Noemí, Martínez-Balbás Marian, de la Cruz Xavier
Primary Institution: Instituto de Biología Molecular de Barcelona, CID, Consejo Superior de Investigaciones Científicas (CSIC)
Hypothesis
Can alternative splicing modulate the function of epigenetic regulators?
Conclusion
Alternative splicing of epigenetic regulators can significantly influence their functional properties, potentially affecting gene expression regulation.
Supporting Evidence
- 49% of the studied epigenetic regulators show alternative splicing.
- 70% of human epigenetic regulators express more than one transcript.
- Alternative splicing can create isoforms that either inhibit or enhance enzyme function.
Takeaway
This study found that many genes that help control how genes are turned on or off can change their shape in different ways, which might change how they work.
Methodology
The study analyzed alternative splicing data from various public databases for 160 epigenetic regulators and assessed the impact on their functional domains.
Limitations
The study relies on data from public databases, which may contain errors or inconsistencies.
Digital Object Identifier (DOI)
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