Urolithin A Protects Hepatocytes from Palmitic Acid-Induced ER Stress by Regulating Calcium Homeostasis in the MAM
2024
Urolithin A Protects Liver Cells from Stress
publication
10 minutes
Evidence: high
Author Information
Author(s): Ryu Gayoung, Ko Minjeong, Lee Sooyeon, Park Se In, Choi Jin-Woong, Lee Ju Yeon, Kim Jin Young, Kwon Ho Jeong
Primary Institution: Yonsei University
Hypothesis
Can Urolithin A alleviate endoplasmic reticulum stress in liver cells caused by palmitic acid?
Conclusion
Urolithin A protects liver cells from palmitic acid-induced stress by regulating calcium levels.
Supporting Evidence
- Urolithin A was shown to bind directly to SERCA, a key protein in calcium regulation.
- Treatment with Urolithin A restored calcium levels in liver cells stressed by palmitic acid.
- Urolithin A reduced markers of endoplasmic reticulum stress in liver cells.
- Urolithin A increased cell survival in palmitic acid-treated liver cells.
Takeaway
Urolithin A helps liver cells stay healthy by keeping calcium levels balanced, especially when they are stressed by fat.
Methodology
The study used cellular thermal shift assays and mass spectrometry to identify Urolithin A's target proteins and their effects on calcium homeostasis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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