Oxygen Therapy in Sepsis Patients on Mechanical Ventilation
Author Information
Author(s): Ghazaly Huda F., Aly Ahmed Alsaied A., Tammam Ahmed S., Hassan Mahmoud M., Hammad Soudy S., Mahmoud Naggeh M., Hemaida Tarek S.
Primary Institution: Aswan University, Egypt
Hypothesis
How do liberal and conservative oxygen therapies influence hemodynamic parameters in mechanically ventilated patients with sepsis?
Conclusion
Liberal or conservative oxygen therapy did not influence stroke volume or cardiac output measurements in mechanically ventilated patients with sepsis, but patients in the conservative group were more likely to require vasopressors.
Supporting Evidence
- Stroke volume and cardiac output did not differ significantly between groups after 72 hours.
- Patients in the conservative oxygen therapy group were 3.83 times more likely to require vasopressors.
- Older patients and those with higher SOFA scores were more likely to need vasopressors.
Takeaway
This study looked at how different oxygen treatments affect sick patients on breathing machines. It found that both treatments worked similarly for heart function, but more patients needed extra help with blood pressure in the conservative group.
Methodology
This randomized clinical trial included 106 patients with sepsis requiring mechanical ventilation, assigned to liberal or conservative oxygen strategies, with outcomes measured using echocardiography.
Potential Biases
Potential bias due to the single-center design and exclusion of certain patient demographics.
Limitations
The study was conducted in a single SICU, which may limit the generalizability of the findings, and it did not analyze laboratory results or collect data on antibiotic use.
Participant Demographics
Patients were adults with sepsis, requiring mechanical ventilation, with a mean age of approximately 48 years.
Statistical Information
P-Value
0.024
Confidence Interval
95% CI: 1.31–11.18
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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