Gene Translation Efficiency in Ashbya gossypii vs. Yeasts
Author Information
Author(s): Jiang Huifeng, Zhang Yue, Sun Jun, Wang Wen, Gu Zhenglong
Primary Institution: Cornell University
Hypothesis
The differences in gene translation efficiency between Ashbya gossypii and yeasts may account for their phenotypic divergence.
Conclusion
The study found that higher translation efficiency of cell cycle genes in Ashbya gossypii may explain its multicellular growth compared to unicellular yeasts.
Supporting Evidence
- The study identified 3,151 orthologous genes between A. gossypii and nine yeast species.
- Group I genes are significantly enriched with cell cycle functions.
- Group II genes are biased toward metabolic functions.
- Fisher's exact test indicates that confirmed cell cycle genes in A. gossypii are enriched in Group I.
Takeaway
This study looked at how genes work differently in a fungus and yeasts, finding that the fungus has genes that help it grow in a special way.
Methodology
Codon usage patterns were compared to identify orthologous genes with different gene regulation between A. gossypii and nine closely related yeast species.
Statistical Information
P-Value
0.003
Confidence Interval
95%
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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