Prognostic Significance of Oestrogen Receptors in Early Breast Cancer
Author Information
Author(s): J. Winstanley, T. Cooke, W.D. George, G. Murray, S. Holt, R. Croton, K. Griffiths, R. Nicholson
Primary Institution: University Department of Surgery, Royal Infirmary, Glasgow
Hypothesis
Does oestrogen receptor status predict long-term survival in early breast cancer?
Conclusion
Oestrogen receptor status has no long-term prognostic value in women with operable breast cancer.
Supporting Evidence
- Oestrogen receptors were present in 54% of tumours.
- Absence of oestrogen receptors was associated with higher histological grade.
- Nodal status and tumour size were found to be powerful independent prognostic factors.
Takeaway
This study looked at whether having oestrogen receptors in breast cancer affects how long patients live. It found that it doesn't really help predict survival.
Methodology
A prospective study assessing oestrogen receptor status in 767 patients with stage I and II breast cancer treated by mastectomy.
Limitations
The study did not include patients receiving systemic adjuvant therapy, which may limit the generalizability of the findings.
Participant Demographics
Patients were women with stage I and II breast cancer, presenting between 1975 and 1981.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
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