Healthy Ketogenic Diet vs Energy-Restricted Diet for Weight Loss
Author Information
Author(s): Lim Su Lin, Tay Melissa, Ang Siew Min, Wai Shu Ning, Ong Kai Wen, Neo Wen Joo, Yap Qai Ven, Chan Yiong Huak, Khoo Chin Meng, Drenowatz Clemens, Greier Klaus
Primary Institution: National University Hospital, Singapore
Hypothesis
The study aimed to investigate the effect of a Healthy Ketogenic Diet (HKD) compared to an Energy-Restricted Diet (ERD) on weight loss and metabolic outcomes among adults with obesity.
Conclusion
The Healthy Ketogenic Diet was more effective than the Energy-Restricted Diet in promoting weight loss and improving cardiometabolic outcomes without increasing LDL-cholesterol levels.
Supporting Evidence
- The HKD group achieved significantly greater mean weight loss at 6 months than the ERD group (−7.8 kg vs. −4.2 kg, p = 0.01).
- The mean weight loss percentage at 6 months was 9.3% for the HKD group compared to 4.9% for the ERD group (p = 0.004).
- Improvements in metabolic profiles were significantly better in the HKD group, including reductions in glycated hemoglobin and systolic blood pressure.
Takeaway
Eating a Healthy Ketogenic Diet can help people lose weight and improve their health without raising bad cholesterol levels.
Methodology
This was a pragmatic randomized controlled trial with 80 participants who were assigned to either the HKD or ERD for 6 months, focusing on weight change and metabolic outcomes.
Potential Biases
Self-reported dietary intake may introduce reporting bias and estimation errors.
Limitations
The study had a relatively small sample size and was conducted at a single center, which may limit the generalizability of the findings.
Participant Demographics
Multi-ethnic Asian adults aged 21 to 65 years with obesity (BMI ≥ 27.5 kg/m2).
Statistical Information
P-Value
0.01
Confidence Interval
95% CI 1.6–131.9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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