Database of MYC-Related miRNA Loops
Author Information
Author(s): El Baroudi Mariama, Corà Davide, Bosia Carla, Osella Matteo, Caselle Michele
Primary Institution: University of Turin
Hypothesis
How do MYC transcription factors cooperate with microRNAs in gene regulation?
Conclusion
The study created a comprehensive database of human mixed transcription factor/microRNA feed-forward loops regulated by MYC.
Supporting Evidence
- The study identified 143 mixed feed-forward loops involving MYC.
- Statistical tests showed significant enrichment of these loops in the regulatory network.
- The database allows for exploration of miRNA and target gene interactions.
Takeaway
The researchers made a big list of how a gene called MYC works with tiny molecules called microRNAs to control other genes in our body.
Methodology
The study used independent databases to identify and characterize mixed microRNA/transcription factor feed-forward loops regulated by MYC.
Potential Biases
Potential bias from assumptions on transcription factor and microRNA binding sequences.
Limitations
The analysis was initially based on bioinformatic evidence, which could introduce bias.
Statistical Information
P-Value
3.8E-11
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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